Data curation process fully automated

CENTOGENE implements ACTICO’s platform to dramatically accelerate and improve the quality of diagnostic data curation workflow.

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CENTOGENE engages in diagnosis and research around rare diseases transforming real-world clinical and genetic data into actionable information for patients, physicians, and pharmaceutical companies. Our goal is to bring rationality to treatment decisions and to accelerate the development of new orphan drugs by using our extensive rare disease knowledge, including epidemiological and clinical data, as well as innovative
biomarkers. CENTOGENE has developed a global proprietary rare disease platform based on our realworld data repository with over 3.6 billion weighted data points from approximately 570,000 patients representing over 120 different countries as of August 31, 2020.


Rare disease diagnoses in minutes, not weeks

For patients who are suffering from an undiagnosed rare genetic disease, receiving a diagnosis as early as possible is vital. As a world leader in genetic diagnostics for rare diseases, Rostock-founded CENTOGENE GmbH is committed to accelerating the diagnosis of these conditions. The company’s partnership with Business Rules specialists S&D, and the implementation of the ACTICO decision management platform, has enabled them to succeed in this aim. How? By automating and optimizing the labor intensive diagnostic data curation process.


Reduce Patient Suffering

  • Diagnosing rare diseases can be a slow and painstaking process, resulting in unnecessary patient suffering.
  • Therefore, CENTOGENE wanted to accelerate the curation of key diagnostic data by integrating artificial intelligence into the relevant workflow.

Accelerated Diagnosis

  • Data curation process fully automated.
  • Data results delivery reduced from one month, to just five minutes.
  • More time for scientists to spend investigating the most difficult cases.

Automation of the Data Curation Process

  • ACTICO Business Rules Engine, implemented in partnership with Business Rules specialists S&D
  • Integration of decision-making automation into the curation workflow, with increasing levels of automation until all manual processing tasks were eliminated.

Business & Patient Value

This case study provides dramatic proof of how the ACTICO platform can deliver significant business value by using a rules-based decision-making engine to automate data curation. In this instance, the business value is enhanced by the benefit to patients of faster, more accurate and continuously updated rare disease diagnosis. Looking to the future, CENTOGENE is keen to replicate their success by applying the same approach to automate other essential processes. Moreover, CENTOGENE is actively exploring how to extend their use of the ACTICO platform to include, for example, the Machine Learning module.

ACTICO Platform in use at CENTOGENE

“We are now able to batch the processing of thousands of patient samples with this fully integrated solution and save up to one month of work for every case.”

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